Saxagliptin antidiabetics cheap and fine
Saxagliptin ONGLYZA™ (Saxagliptin saxagliptin tablets) is a highly
effective Dipeptidyl Peptidase 4 (DPP-4) inhibitor that selectively
inhibits DPP-4, It can increase endogenous levels of glucagon-like
peptide-1 (GLP-1) and glucose-dependent Insulinotropic Peptide
(GIP), thus regulating blood Glucose.Saxagliptin, Sax, a potent
selective DPP-4 inhibitor, can specifically prolong the inhibition
of DPP-4, thereby prolonging the duration of action of endogenous
GLP-1 and GIP to reduce blood glucose. On May 5, 2011, Sax received
marketing approval in China (trade name Enrizer) for the treatment
of TZDM.
1. Pharmacological effects
The mechanism of action is that it works by blocking the
degradation of GLP-1, a hormone naturally produced in the intestine
after ingestion of food, which regulates insulin secretion and
enhances glucose utilization in surrounding tissues.
2. Pharmacokinetics
The plasma concentrations of saxagliptin were dose-proportional and
had similar pharmacokinetic parameters in healthy subjects and
patients with type 2 diabetes. In patients with type 2 diabetes,
saxagliptin inhibits DPP-4 activity for up to 24 h. Inhibition of
dPP-4 by saxagliptin leads to a 2-3 fold increase in glP-1 and GIP
activity after oral glucose or meal, and decreases glucagon
concentration, increasing insulin secretion by pancreatic beta
cells in a glucose-dependent manner. The time to reach the maximum
plasma drug concentration was < 2 h, and the calculated mean
half-life was 2.2-3.8 h. Further studies have shown that older
subjects (≥ 65 years) receiving a single dose of 10 mg of
saxagliptin have less than a twofold increase in exposure compared
with younger subjects (18-40 years). Therefore, there is no need to
adjust the dose of saxagliptin according to age.
Approximately 70% of saxagliptin can be recovered in urine,
indicating that saxagliptin can be widely absorbed after oral
administration. Saxagliptin can be cleared through metabolism (21%
-- 52% of the dose administered is recovered in the urine as major
metabolites) and renal excretion (12% -- 29% of the dose
administered is cleared in the urine as mother drug). A recent
study evaluated the effects of renal insufficiency and hemodialysis
on the pharmacokinetics of saxagliptin. In this study, the degree
of renal insufficiency did not affect the Cmax of saxagliptin or
its major metabolites. The mean global systemic exposure (AUC) of
saxagliptin and its major metabolites in subjects with mild renal
insufficiency was 1.2 times and 1.7 times higher than that in
subjects with normal renal insufficiency, respectively. AUC values
were 1.4 and 2.9 times higher in subjects with moderate renal
insufficiency than in subjects with normal renal function,
respectively. The corresponding values were 2.1 and 4.5 times,
respectively, in subjects with severe renal insufficiency.
Hemodialysis at 4 h can remove 23% of the dose of Sax. [2]
Our Competitive Advantages:
1. Rich experience: we specialize in this field for many years, our
steroids have been exported almost over the world. Such as USA,
Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland,
Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania,
Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia,
Singapore, other Middle East countries, European countries,
American countries and more Areas.
2. Great quality: High purity and Favorable price. Good quality is
the first base of our success. All of our products enjoys high
purity. Thus, it can make sure your demand. Welcome order the
samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing
methods, experience in choosing express, 4~7 days to arrive,
successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we
offer hormone solution and Recipes. We can teach you or discuss how
to make hormone solution on the site. Any discussion and question
is welcome!
Packaging & Service:
1. Mass stock, to make sure delivery promptly every day when the
payment is done.
2. Having been engaged in this field for years, we have
sophisticated and professional logistics department, which can
guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional
enough to provide you a safe package. It also avoid a lot of
emergency happen during the delivery so that high customs pass is
guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or
100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking number are provided within 24 hours
as soon as receiving the payment. Updated tracking code will be
provided every other day just for you can hold a palm of your
package.
5. Perfect after-sale service: Any questions or problems happened
after receiving the product.
Please feel free to contact us. 24/7 online to solve your various
problems!
